CLRLY Formula 4: Barrier Defense contains astragalin, a plant flavonoid extracted from the astragalus flower. Astragalin (kaempferol-3-O-glucoside) is a powerful antioxidant that modulates the pro-inflammatory immune response by inhibiting the master regulator of inflammation, nuclear factor kappa beta (NF-κB). In doing so, astragalin protects the body from excessive immune activation, especially under various forms of stress related to inflammation, physical activity, environmental conditions or psychosocial factors. This shifts the metabolism towards aerobic respiration and higher ATP production and away from glycolysis (cancer, lactate production). This helps prevent leaky gut and seals the blood brain barrier.
Research-based benefits of astragalin include:
- Seals blood brain barrier
- Maintains gut barrier integrity
- Prevents LPS damage from leaky gut
- Supports liver detoxification
- Antiviral and antibacterial
- Lowers ROS and RNS
- Increases ATP production
- Reduces lactate production
- Promotes BDNF and neurogenesis
- Alleviates depressive disorders
- Prevents cognitive decline
Unprecedented antigenic pressure in the modern environment is driving the decline in collective well-being. Stay ahead of the pack with F4 and by periodically cycling the CLRLY Protocol. Stop guessing with your health— objectively track progress with the recommended CLRLY bloodwork (CLRLY20 for 20% off). It’s survival of the fittest, congratulations on making it this far, Anon.
Dosing: Take 1-2 pills on an empty stomach or with food for best absorption. Take with carbs/sugar for sleep benefits— before bed or early in the morning to extend sleep duration. Take with carbs prior to exercise to enhance physical performance. Do not take after workouts as antioxidants can inhibit adaptive signaling.

