CLRLY is honored to present the first supplement of its kind: Formula 4, Barrier Defense. F4 contains astragalin, a plant flavonoid extracted from the astragalus flower.
Astragalin (kaempferol-3-O-glucoside) is a powerful antioxidant that turns off the pro-inflammatory immune response by inhibiting the master regulator of inflammation, nuclear factor kappa beta (NF-κB). By inhibiting NF-κB gene transcription, astragalin protects the body from excessive immune activation, especially under various forms of stress related to inflammation, physical activity, environmental conditions or psychosocial factors. This helps prevent leaky gut and seals the blood brain barrier.
More specifically, it reduces pro-inflammatory cytokine production within macrophages and glial cells which promotes mitochondrial gene expression that shifts the metabolism towards aerobic respiration and higher ATP production and away from glycolysis (cancer, lactate production) and inflammation.
Research-based benefits of astragalin include:
- Seals blood brain barrier
- Maintains gut barrier integrity
- Prevents LPS damage from leaky gut
- Supports liver detoxification
- Antiviral and antibacterial
- Lowers ROS and RNS
- Increases ATP production
- Reduces lactate production
- Promotes BDNF and neurogenesis
- Alleviates depressive disorders
- Prevents cognitive decline
Cumulatively, F4 buffers the effects of biological and social stressors modernity presents while supporting healthy adaptation to these stressors. Welcome our new friend and ally in the line-up of CLRLY designer formulas, Anon, the next level awaits...
Dosing: Take 1-2 pills on an empty stomach or with food. If experiencing health issues, F4 can be taken liberally. If already healthy, take during the day or prior to exercise for maximum benefit. When optimized, excessive antioxidant consumption at night can shorten sleep duration. Be mindful of dosage timing and amount, cycle as needed. For best results, take in conjunction with the CLRLY detox protocol.