{"product_id":"f4-barrier-defense","title":"NEW- CLRLY F4- Barrier Defense","description":"\u003cp\u003eCLRLY is honored to present the first supplement of its kind:\u003cstrong\u003e Formula 4, Barrier Defense.\u003c\/strong\u003e F4 contains \u003cstrong\u003eastragalin\u003c\/strong\u003e, a \u003cstrong\u003eplant flavonoid\u003c\/strong\u003e extracted from the astragalus flower.\u003c\/p\u003e\n\u003cp\u003eAstragalin (k\u003cspan class=\"a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none\"\u003eaempferol-3-O-glucoside)\u003c\/span\u003e is a powerful antioxidant that \u003cstrong\u003eturns off the pro-inflammatory immune response\u003c\/strong\u003e by inhibiting the master regulator of inflammation, \u003cmeta charset=\"utf-8\"\u003enuclear factor kappa beta (NF-κB). By inhibiting NF-κB gene transcription, astragalin\u003cstrong\u003e \u003c\/strong\u003eprotects the body from excessive immune activation, especially under various forms of stress related to inflammation, physical activity, environmental conditions or psychosocial factors. This \u003cstrong\u003ehelps prevent leaky gut\u003c\/strong\u003e and \u003cstrong\u003eseals the blood brain barrier\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp\u003eMore specifically, it \u003cstrong\u003ereduces pro-inflammatory cytokine production\u003c\/strong\u003e within macrophages and glial cells which promotes mitochondrial gene expression that shifts the metabolism towards \u003ca href=\"https:\/\/clrly.com\/blogs\/journey\/the-nad-nadh-ratio-and-aerobic-respiration\"\u003eaerobic respiration\u003c\/a\u003e and higher ATP production and away from \u003ca href=\"https:\/\/clrly.com\/blogs\/journey\/anaerobic-glycolysis\"\u003eglycolysis\u003c\/a\u003e \u003cmeta charset=\"utf-8\"\u003e(cancer, lactate production) and inflammation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eResearch-based\u003c\/strong\u003e benefits of astragalin include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan class=\"a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none\"\u003eSeals blood brain barrier\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none\"\u003eMaintains gut barrier integrity\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none\"\u003ePrevents LPS damage from leaky gut\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none\"\u003eSupports liver detoxification\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none\"\u003eAntiviral and antibacterial\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none\"\u003eLowers ROS and RNS\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none\"\u003eIncreases ATP production\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none\"\u003eReduces lactate production\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none\"\u003ePromotes BDNF and neurogenesis\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none\"\u003eAlleviates depressive disorders\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none\"\u003ePrevents cognitive decline\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan class=\"a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none\"\u003eCumulatively, \u003cstrong\u003eF4 buffers the effects of biological and social stressors\u003c\/strong\u003e modernity presents while supporting healthy adaptation to these stressors. Welcome our new friend and ally in the line-up of CLRLY designer formulas, Anon, the next level awaits...\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan class=\"a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none\"\u003eDosing: \u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none\"\u003eTake 1-2 pills on an empty stomach or with food. \u003c\/span\u003e\u003cspan class=\"a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none\"\u003eIf experiencing health issues, F4 can be taken liberally. If already healthy, take during the day or prior to exercise for maximum benefit. When optimized, excessive antioxidant consumption at night can shorten sleep duration. Be mindful of dosage timing and amount, cycle as needed. For best results, take in conjunction with the CLRLY detox protocol. \u003c\/span\u003e\u003c\/p\u003e","brand":"CLRLY","offers":[{"title":"Default Title","offer_id":47978976018587,"sku":null,"price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0091\/5190\/5858\/files\/f4bottle.jpg?v=1775054608","url":"https:\/\/clrly.com\/products\/f4-barrier-defense","provider":"CLRLY","version":"1.0","type":"link"}